Livatone® Plus has the same benefits as the Livatone® and in addition, because of its more extensive list of synergistic ingredients, can be beneficial for people with many types of liver damage. This high potency herbal and nutritional formula, is essential in promoting liver detoxification and health. It supports Phase One and Phase Two detoxification pathways ensuring optimum detoxification with reduced side effects.
Livatone® Plus Capsules contain herbs that are traditionally used as a liver tonic to help maintain healthy digestive function.
Livatone Plus contains the following natural ingredients:
Thiamin (Vitamin B1)
Riboflavin (Vitamin B2)
Nicotinamide (Vitamin B3)
Calcium Pantothenate (Vitamin B5)
Pyridoxine (Vitamin B6)
Cyanocobalamin (Vitamin B12)
St. Mary's Thistle (Milk Thistle)
A brief description of Ingredients:
ST. MARY'S THISTLE (MILK THISTLE)
Thistle also known as "Silybum Marianum", is a herb with remarkable
detoxifying and liver protective effects. It is a very well known liver
herb, having been recommended in herbal texts since the late 1600's. Its
most active constituent is silymarin, which is a bioflavonoid. Research
has shown that Milk Thistle can protect against some severe liver
For example the poisonous mushroom "Amanita
phalloides" leads to death in 40% of people who ingest it. This mushroom
contains the toxins, phalloidin and amanitin, which are highly
destructive to liver cells. Extracts of Milk Thistle containing the
active ingredient silymarin, can protect the liver from phalloidin. Some
animal experiments found that silymarin was 100% effective in
preventing toxicity when given before poisoning by the mushrooms.
Silymarin was also effective if given to the poisoned animals within 10
minutes after ingestion. Furthermore, if silymarin was given within 24
hours after ingestion it still prevented death, and greatly reduced the
severity of liver damage.
Silymarin also protects the liver in
animals exposed to alcohol, and the solvent carbon tetrachloride. Liver
disorders in humans have been treated with silymarin with promising
results. Patients with chronic hepatitis (liver inflammation) had
improvements in liver function after taking silymarin for 3 months. Most
liver toxins, including alcohol, produce damage to cell membranes via
free radical generation.
Silymarin functions as an antioxidant
and reduces damage to cell membranes. It prevents the formation of
leukotrienes, which are dangerous inflammatory chemicals produced by the
immune system. Silymarin can increase the quantity of the powerful
liver protector glutathione, and improves protein synthesis in the
Specific amino acids are essential for the liver to breakdown toxins and drugs and also for the efficient metabolism of nutrients by the liver.
This amino acid is required for phase two detoxification in the liver and is required in increased amounts by those who consume excessive alcohol. It is able to reduce the craving for alcohol. Glutamine supplementation is helpful for intestinal disorders such as peptic ulcers and leaky gut syndrome. Leaky gut is the term used to describe an inflamed condition of the lining of the bowel, which makes the bowel too permeable, so that toxins and incompletely digested food particles can be absorbed from the bowels directly into the liver. This increases the workload of the liver and may cause many health problems. Glutamine is used as fuel by the brain and by the lymphocytes (white blood cells). It is essential for the lymphocytes to fight viruses such as hepatitis B and C.
Glutamine is converted in the body into glutamic acid, which, along with the amino acids cysteine and glycine, is converted into the powerful liver protector glutathione.
Glutathione is essential for liver phase two conjugation reactions used during detoxification of drugs and toxic chemicals.
Glutathione is a potent antioxidant that is produced in the healthy liver where it neutralizes oxygen molecules before they can damage cells. Glutathione is a component of the antioxidant enzyme glutathione-S-transferase, which is a widely acting liver-detoxifying enzyme. Indeed large amounts of glutathione are stored in the liver, where it detoxifies harmful compounds so they can then be excreted via the bile. Glutathione helps to reduce damage from cigarette smoke, alcohol, radiation, heavy metals, drugs and chemotherapy. Glutathione plays a vital role in preventing liver cancer. Glutathione levels decline with age, and this may accelerate the aging process. It is not worth taking glutathione supplements, as they are expensive and usually poorly absorbed. It is far more effective to increase glutathione levels by giving the liver, the raw materials it needs to make its own glutathione, namely, the amino acids glycine, glutamine and cysteine.
This amino acid performs more biochemical functions than any other amino acids. It is required for the synthesis of bile salts, and is used by the liver to detoxify chemicals in the phase-two detoxification pathways.
Inadequate levels of taurine are common in those patients with chemical sensitivities, allergies and poor diets. Taurine is the major amino acid required by the liver for the removal of toxic chemicals and metabolites the liver to detoxify environmental chemicals such as chlorine, chlorite (bleach), aldehydes (produced from alcohol excess), alcohols, petroleum-based solvents and ammonia. Recent findings are demonstrating that taurine is one of the major nutrients involved in the body's detoxification of harmful substances and drugs, and should be considered in the treatment of all chemically sensitive patients.
Taurine is helpful for fatty liver, high blood cholesterol and gall bladder problems, alcohol withdrawal, hepatitis and jaundice. Taurine is a sulfur bearing amino acid that is present in all good liver tonics for very good reasons. It is required for the healthy production of bile, and the liver uses it to conjugate toxins and drugs to excrete through the bile. It helps the liver to excrete excessive cholesterol out of the body through the bile, and thus is an aid to weight control and cardiovascular health. Doses required can vary from 50 to 2000 mg daily. It is free of side effects but should not be taken on an empty stomach in those with stomach ulcers. It is found in animal protein such as meat, seafood, eggs and dairy products but not in vegetable protein.
Taurine is often deficient in strict vegans. Taurine regulates the transport of minerals across cell membranes and stabilizes the electrical properties of cell membranes. For this reason, a deficiency of taurine has been linked to epileptic seizures, and combined with vitamin B 6, it has a useful anti-seizure effect in epileptics. It is made from two other amino acids methionine and cysteine.
Cysteine is an amino acid that contains sulfur, and is needed by the phase-two detoxification pathway. It is a precursor of glutathione, which is needed to breakdown pollutants and toxins and has powerful antioxidant effects. Aldehydes, which are toxic breakdown products of alcohol, rancid fats and smog, are partially neutralized by cysteine.
A study reported that large doses of acetaldehyde (derived from alcohol), killed 90% of the mice that consumed it. A control group of mice were primed with vitamin C, vitamin B 1 and cysteine, and were then given the equivalent amount of acetaldehyde that had killed 90% of the other mice. None of the supplement-primed mice in the control group died.
Antioxidants destroy free radicals and so help to detoxify and protect the cells of the body, including the liver cells, from toxins.
Vitamin C is the most powerful antioxidant vitamin for the liver and reduces toxic damage to the liver cells from chemical overload. It neutralizes free radicals generated during the phase 1 detoxification pathway in the liver. Toxic chemicals are far less dangerous if there is plenty of vitamin C in the liver. It helps the liver to regulate cholesterol levels and improves immunity.
Natural vitamin E is biologically more active than synthetic vitamin E. Vitamin E is a powerful antioxidant that protects fats from damage. Since cell membranes are composed of fats, vitamin E is the best protector of cell membranes. It does this by preventing free radicals from oxidizing cell membranes, which prevents them from becoming rancid. Thus vitamin E can help to protect the membranes surrounding liver cells. Vitamin E is also needed in those with a "fatty liver", where there is an accumulation of unhealthy oxidized fats in the liver cells.
Carotenoids such as betacarotene are most commonly found in fruits and vegetables and are most significant for human health. It is important to take only natural sources of beta-carotene and other carotenoids. Beta-carotene gets converted in the body to vitamin A and yet has none of the toxic side effects of high doses of vitamin A. Large population studies have shown that low intakes of beta-carotene are associated with a higher incidence of cancer. Beta-carotene is a powerful protective antioxidant.
B GROUP VITAMINS
Thiamin (Vitamin B 1)
This B vitamin has antioxidant properties and is helpful in reducing the toxic effects of alcohol, smoking and lead. Thiamin protects against many of the metabolic imbalances caused by alcohol. Deficiency of thiamin is common in those who consume excessive alcohol and this will often lead to poor mental function.
Riboflavin (Vitamin B 2)
This B vitamin is required during phase one detoxification in the liver, and is crucial in the production of body energy. Riboflavin deficiency is common in those who consume excessive alcohol and should be supplemented in such cases.
Nicotinamide (Vitamin B 3)
This is also known as Niacinamide, and is required by the liver's phase one detoxification system. It is needed for the metabolism of fats and helps to keep cholesterol levels under control.
Calcium Pantothenate (Vitamin B 5)
Several studies have found that pantothenate can lower cholesterol (by an average of 15%), and triglycerides (by an average of 30%) in those with elevated levels of these blood fats. A study showed that pantothenate speeds up liver detoxification of acetaldehyde after alcohol consumption. This is very important for those who consume excessive alcohol because acetaldehyde appears to be a major chemical in the toxic process that accompanies long term alcohol use. Pantothenate is required in increased amounts in liver disease and in those who use alcohol excessively.
Pyridoxine (Vitamin B 6)
Vitamin B 6 is required for effective phase one liver detoxification, and is essential for physical and mental health. Vitamin B 6 inhibits the formation of a toxic chemical called homocysteine, which accelerates cardiovascular disease.
Cyanocobalamin (Vitamin B 12)
Supplements of this powerful vitamin are essential for those who are strict vegetarians or those with nervous complaints. It is a great energizer of the nervous system and can reduce depression and fatigue. It is required for phase one detoxification of chemicals in the liver, and can help people who are allergic to sulfites, which are common food and wine additives. A study showed that vitamin B 12 can effectively block most of the adverse reactions to sulfites such as hay fever, sinus, headache and bronchial spasms. B 12 is required for the liver to perform methylation, which inactivates the hormone estrogen and enhances the flow of bile. B 12 is required in increased amounts by those who use alcohol excessively, or in liver disease and pernicious anemia.
Is required for the phase one detoxification pathway in the liver and for cell repair and division. There is an increased need in alcohol excess. Some studies have shown that folic acid exerts an anticancer effect.
Biotin is one of the B vitamins and is produced in the intestines by friendly bacteria. It is found in foods such as nuts, whole grain foods, vegetables and brewer's yeast, and in supplement form. Liver cells that lack biotin will be deprived of the energy they need to detoxify chemicals and drugs. Deficiency of this vitamin is not rare and can cause hair loss, dry flaky skin, rashes and fatigue. Those with a poor diet, alcoholism or long term antibiotic use, are at risk of deficiency.
This vitamin is important in fat metabolism, and helps to remove fats from the liver. Deficiency of inositol can increase hardening of the arteries, increase blood cholesterol levels and lead to hair loss, constipation and mood swings. Excessive consumption of caffeine can reduce the level of inositol in the body.
Lecithin contains healthy fats, which are required for the functional and structural integrity of cell membranes. Lecithin is composed of the B vitamin choline, along with linoleic acid and inositol. A choline deficiency promotes liver damage and can be corrected with lecithin supplements. Choline has shown a protective effect against cirrhosis in animal studies.
Trials are now being done to see if this protective effect can be reproduced in humans. Lecithin is vital for fat metabolism and allows cholesterol to disperse in watery solutions so that it can be transported around the body to where it is needed, or removed from the body. This reduces the risk of fatty degeneration in arteries and vital organs. It can help those with the condition of fatty liver caused by incorrect diet or alcoholism.
The mineral zinc has antioxidant properties and is part of the powerful antioxidant enzyme called superoxide dismutase (SOD). Zinc is vital for the efficient functioning of the cellular immune system needed to fight infections from viruses, parasites and fungal microorganisms.
Cruciferous vegetables such as broccoli, cauliflower, cabbage, Brussels sprouts, kale, bok choy, mustard greens and radish, contain important substances such as indoles, thiols and sulfur compounds, which enhance the liver's phase one and two detoxification pathways.
Broccoli has a particularly good effect and enhances glutathione conjugation of toxins. There is evidence that cruciferous vegetables are able to reduce the risk of cancer, and the American Cancer Society have been placing large advertisements in magazines with pictures of these vegetables, saying that "A defense against cancer can be cooked up in your kitchen. "
Green tea exerts strong antioxidant actions and is also able to inhibit cancer cell growth. The Chinese, who are large drinkers of green tea, have a 60% less chance of esophageal cancer. Parts of Japan where people drink a lot of green tea have a lower incidence of many types of cancers, including stomach, esophageal and liver cancer. Green tea may also be of benefit as an aid to weight loss through positive effects on fat and sugar metabolism.
Livatone Plus contains all of the preceding ingredients finely ground and mixed together in capsule form.
This is far more practical, economical and convenient than having to take them all individually.Two capsules just before food, twice daily. Take this dosage for eight to twelve weeks. Then go on to a maintenance dose of two capsules daily, which can be continued for as long as needed.
Some people find that they need to stay on a liver tonic in a maintenance dose permanently because of dysfunctional liver problems and the extra challenges faced by the liver in this day and age. Those who have a very dysfunctional liver, a fatty liver, or problems with excessive weight, can continue safely on the higher dose.
When beginning any liver tonic for the first time, always commence with a low dosage (say one quarter of the recommended dosage, e.g.. 1 capsule daily), and stay on this low dose for the first week. Beginning with the maximum dose of a liver tonic may stimulate the liver's release of toxins too quickly, which could cause nausea, vomiting or headaches.
Per 2 capsules
- Milk Thistle Seed Extract 262.5mg (Silymarin 210mg)
- Vitamin C (as ascorbic acid) 105mg
- d-alpha tocopheryl succinate (vitamin E) 200iu
- Thiamine hydrochloride (B1) 11mg
- Riboflavin (B2) 11mg
- Nicotinamide (B3) 11mg
- Pyridoxine hydrochloride (B6) 11mg
- Folic Acid 240mcg
- Methylcobalamin (Vitamin B12) 60mcg
- Biotin 60mcg
- Calcium pantothenate (equiv pantothenic acid 22mg)(B5) 27.5mg
- Zinc (as zinc oxide) 7mg
- Selenium (as selenomethionine) 50mcg
- Livatone® Plus Nutritive base 379mg Taurine, phosphatidyl choline from soya lecithin, broccoli powder, L - Cysteine, HCI, L-Glutamine , Glycine, Inositol, natural caretenoids, (Camelia sinensis (green tea) extract, L - glutathione)
- Veggie Cap, Cellulose fiber, Magnesium stearate and silica.
- Livatone® Plus PROVIDES 420mg DAILY OF PURE SILYMARIN, WHICH IS THE PROVEN DOSE, AS TESTED IN NUMEROUS CLINICAL TRIALS.