Does Curaderm Work on Squamous Cell Carcinoma?

Posted by Dr. Stan Guberman on 1/31/2025

As a healthcare professional I get asked all the time if Curaderm works on squamous cell carcinoma. Patients looking for non invasive alternatives to traditional treatments are drawn to this topical cream because it targets abnormal skin cells. But how does it work and is it a viable option for squamous cell carcinoma (SCC)? Let’s take a look.

What is Squamous Cell Carcinoma

Squamous cell carcinoma is the second most common type of skin cancer after basal cell carcinoma. It occurs in the squamous cells that make up the outermost layer of the epidermis, and most often generated through long-term sunlight exposure.

Key Characteristics of SCC:

Appears as scaly patches, red sores, or warts
They most frequently occur in sunlight-exposed regions, such as face, ears, neck, and hands
Can spread if left untreated especially in high risk individuals
Often requires medical care such as excision, Mohs surgery, or topical therapy

Because SCC can spread, early detection and treatment is key. Many patients look for alternative solutions before surgery so that’s where Curaderm comes in.

How Does Curaderm Work?

Curaderm is a topical cream containing Solasodine Glycosides (BEC5), a plant based compound that targets and eliminates abnormal skin cells while leaving healthy tissue intact.

Curaderm’s Mechanism of Action:

Identifies Abnormal Cells – The active ingredient, BEC5, binds to cancerous and pre-cancerous cells without affecting normal skin.
Triggers Apoptosis – Once inside the affected cells, it disrupts their function and causes programmed cell death (apoptosis).
Supports Natural Healing – Over time the damaged cells are removed and the skin can regenerate and repair itself naturally.

Research has shown that Curaderm has been effective in treating basal cell carcinoma (BCC) and some cases of actinic keratosis, but what about squamous cell carcinoma?

Is Curaderm Effective for Squamous Cell Carcinoma?

The effectiveness of Curaderm on SCC is not as well-documented as its success in treating basal cell carcinoma. Clinical studies and patient reports suggest that Curaderm may work on early-stage SCC or SCC in situ (Bowen’s disease), but it is not recommended for invasive squamous cell carcinoma.

When Might Curaderm Work for SCC?

For superficial or early-stage SCC that has not deeply invaded the skin
When used under medical supervision to ensure proper monitoring
As a complementary approach alongside other skin-supportive treatments

When Curaderm Is NOT Recommended for SCC

For invasive or aggressive squamous cell carcinoma that may spread to lymph nodes or internal organs
If there is significant tumor depth, as Curaderm only works on surface-level skin lesions
Without a proper diagnosis, since some cases of SCC require surgical removal to prevent metastasis

If you suspect squamous cell carcinoma, I strongly recommend seeing a dermatologist or oncologist for a proper evaluation before considering Curaderm or any alternative treatments.

What Are the Best Treatment Options for SCC?

While Curaderm may be an option for early-stage or superficial SCC, the best treatment depends on the severity and depth of the carcinoma.

Common Medical Treatments for SCC:

Mohs Surgery – A precise technique that removes cancerous layers while preserving healthy skin
Excision – Surgical removal of the tumor with clear margins
Cryotherapy – Freezing the cancer cells with liquid nitrogen
Topical Chemotherapy – Prescription creams like 5-fluorouracil (5-FU) or imiquimod

Should You Use Curaderm for Squamous Cell Carcinoma?

If you are considering Curaderm for squamous cell carcinoma, here’s what you should keep in mind:

Consult a healthcare provider before starting any treatment for SCC.
Early-stage SCC may respond to Curaderm, but deeper or more advanced cases require professional medical intervention.
Monitor your skin’s response if using Curaderm and discontinue use if the lesion worsens or spreads.

While Curaderm has shown promise for basal cell carcinoma, its role in treating squamous cell carcinoma is still debated. If you’re looking for a natural skin health solution, it’s worth discussing with your doctor to determine if it’s appropriate for your specific condition.

If you’re interested in learning more about Curaderm, explore our available treatments today!