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MegaQuinone K2-7-60 capsules
MegaQuinone K2-7-60 capsules

MegaQuinone K2-7-60 capsules

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Vitamin K2: Arguably the Most Important Supplement to Take
Product Number: 8699
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Vitamin K2 has been featured in the press a lot lately, and for good reason. This little known vitamin plays a critical role in heart, brain, bone, and endocrine health, and people simply don’t get sufficient quantities through their diets.
Recently, Microbiome Labs’ chief science officer Kiran Krishnan was interviewed by Rebel Health Tribe founder Michael Roesslein.  K2 is one of the very few supplements that Roesslein recommends to the general population primarily because so few people get sufficient quantities in a typical Western diet. 
In the following paragraphs you’ll find a summary of the interview, but feel free to watch the entire interview by clicking here:

Interviewer: Michael Roesslein, Co-Founder at Rebel Health Tribe, Inc.
Interviewee: Kiran Krishnan, Microbiologist and Chief Science Officer of Physicians Exclusive, LLC. 

There are two forms of vitamin K, phylloquinone (also known as K1) and menaquinone (also known as K2).

Vitamin K1: Sources and Activity
You are likely familiar with vitamin K1—unless otherwise noted, it is the vitamin K that you will find in many multivitamins. Vitamin K1 is:

  • Found mostly in leafy green vegetables such as kale, spinach, Brussels sprouts and broccoli.
  • Named for its role in coagulation (koagulation in Danish).
  • Blood thinning drugs like warfarin work by inhibiting vitamin K-dependent activation of certain coagulation factors. If you are taking warfarin, you should keep dietary intake of vitamin K consistent, and consult with your physician before considering vitamin K supplementation.
Vitamin K2: Sources and Activity
One of the reasons you haven’t heard of vitamin K2 is that it was assumed to be a different form of K1. Researchers now know that K2 has its own important roles in human health apart from coagulation.
  • The liver packages vitamin K2 into lipoproteins before delivering them to the rest of the body.
  • Some of the highest concentrations are found in the brain.[i] [ii]
  • Found in highest quantities in a fermented soy product, natto. Vitamin K2 is also found in fermented cheeses, grass-fed butter and organ meats from healthy animals.
  • K2-7, the form of vitamin K2 present in natto, has greater biological activity than K2-4, the synthetic form of vitamin K2. Along with being the most bioavailable form, K2-7 is also the most stable form.
  • Bacillus spores produce some amount of K2-7 in the gut.
  • Synthetic K2-4 and natto are both used as medicine in Japan. The primary use of K2-4 is osteoporosis, and natto is used as a treatment for dementia.
  • The primary role of vitamin K2 is to carboxylate (activate) vitamin K-dependent proteins (VKDPs) that then perform essential functions in the body.
  • Vitamin K-dependent proteins are responsible for bone production, cardiovascular health, energy production and brain health.
High Dose Vitamin D Supplementation Without K2: Risk for Hypervitaminosis
Vitamin D deficiency is extremely common in the West, as is very high dose supplementation of D3 in order to correct these deficiencies. But what happens when you regularly take high doses of D3? A fat soluble vitamin, D3 can accumulate in tissues, promoting vitamin D toxicity (hypervitaminosis D).
Because vitamin D enhances the intestinal absorption of calcium, too much vitamin D can cause hypercalcemia and calcification of arteries, kidneys, and other organs. 

But what if you are low in vitamin D and need to supplement?
You need to make sure that the calcium you absorb makes it to your bones, rather than ending up in your arteries or organs.
Osteocalcin is one of the proteins activated by vitamin K2. It takes calcium out of the blood and uses it to create bone. Vitamin D triggers the release of the inactive version of osteocalcin which then requires K2 to remove calcium from the blood and add it to bone.
High dose vitamin D supplementation combined with a K2 deficiency (which is tremendously common) will lead to increased levels of inactivated osteocalcin and therefore an increase in calcification of arteries and tissues.
High levels of un- or under-carboxylated osteocalcin will increase your risk for osteopenia, osteoporosis, and hardening of the arteries (atherosclerosis).


[i] Crivello, N., Casseus, S., Peterson, J., Smith, D., & Booth, S. (2010). Age- and brain-region-specific effects of dietary vitamin K on myelin sulfatides. The Journal of Nutritional Biochemistry21(11), 1083–1088.
[ii] Okano, T., Shimomura, Y., Yamane, M., Suhara, Y, Kamao, M, et al. (2008). Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice. Biol Chem 283:11270-11279.
Vitamin K2: Bone and Cardiovascular Health
So how exactly does vitamin K2 help calcium get into bones? Another vitamin K2-dependent protein, Matrix Gla Protein (MGP), removes calcium from the blood vessels. If you can’t activate MGP, you risk calcification of your arteries as shown in some early studies in mice with blocked MGP. These mice died of massive calcification in their arteries within 8 weeks of birth.[i]  Studies in humans show that MGP is active in both soft tissue and blood vessel calcification.
In a few extreme cases, you can see a honeycomb structure in arteries that is attributed to inactivated MGP.
Researchers are increasingly studying vitamin K2 and its relationship to bone and cardiovascular health:
Rotterdam Study, 2004[ii]:
  • This population-based study followed 4807 subjects for 10 years.
  • Participants were split into two groups, with one receiving minimal K2 supplementation and the control group received none.
  • Kiran pointed out that the group receiving the minimal, suboptimal dose of K2 had more than 50% lower mortality risk from cardiovascular disease.
Atherosclerosis, 2009[iii]:
  • A cross-sectional study of 564 post-menopausal women looked at K2 intakes in relation to coronary calcification.
  • A higher K2 intake was associated with a decreased coronary calcification risk.
Clinical Chemistry, 2000[iv]:
  • This study monitored the bone remodeling of two cosmonauts before, during and after space flights.
  • Undercarboxylated osteocalcin increased early and remained high through the flights
  • Vitamin K supplementation restored carboxylation of osteocalcin
JPOS (Japanese Population-Based Osteoporosis) Study, 2006[v]:
  • This study looked at how the intake of natto (high in K2-7) influences bone mineral density and bone mineral change over time.
  • Natto intake helped prevent postmenopausal bone loss
British Journal of Medicine, 2012:
  • This study looked at the health of post- and peri-menopausal women supplementing with calcium
  • For every one positive result related to osteopenia/osteoporosis, there were two negative heart-disease related results.
Kids and Bone Health
Our bodies begin to lose bone density in our late 20s to 30s. There are many ways to prevent bone loss, including a healthy diet, strength training and supplementation, but some degree of bone loss appears unavoidable. Therefore, it is especially important to consider whether our children are getting the nutrients they need to form strong bones.
Kiran mentions in the interview that children’s bones regenerate or turn over at approximately 8 times the rate of adults. Osteocalcin concentrations are very high in young children, eventually reaching adult levels at puberty. Because of all this activity building bone, children have an increased need for nutrients that support calcium utilization. Unfortunately, many children’s diets don’t include the right nutrients to create bone.
While studies on children are more limited, the evidence suggests that vitamin K status directly influences bone development and metabolism:
British Journal of Nutrition, 2008[vi]:
  • This longitudinal study looked how vitamin K2 influenced bone mass acquisition in healthy children
  • Children who had better vitamin K status were associated with a marked increase in total body bone mineral creation.
Vitamin K2: Diabetes, Cancer & Neurological Diseases
Beyond bone and heart health, vitamin K2 plays important roles in diabetes, insulin sensitivity, and various types of cancer. And K2 researchers are increasingly seeing a role in neurological diseases such as Parkinson’s.
Here are some of the highlights:
American Journal of Clinical Nutrition (the EPIC-Heidelberg study), 2008[vii]:
  • 25,000 participant study with approximately 12,000 men.
  • This study evaluated the association between dietary intake of K2 and total and advanced prostate cancer.
  • There was an inverse association between total prostate cancer and total K2 intake with the strongest association with advanced prostate cancer.
Diabetes Care, 2010[viii]:
  • This prospective cohort study featured 38,000+ Dutch men and women aged 20-70
  • Dietary K2 intakes were assessed using a food frequency questionnaire
  • Increased intake of K2 showed a linear, inverse association with risk of type 2 diabetes
Early Parkinson’s Research, 2012[ix]:
  • K2 shows promise in an animal model to treat mitochondrial pathology, as we see in Parkinson’s patients suffering from a Pink1 or Parkin deficiency.
 American Journal of Medicine:
  • This study looked at people with hepatitis and their risk of liver cancer. Normally, people with Hep B and C have a much higher risk of liver cancer than the general population.
  • One group was supplemented with K2, one was not.
  • The K2 group had a 10% chance of developing liver cancer, as opposed to the control group without K2 who had a 47% chance of cancer.
Kiran also mentioned other health conditions where K2 shows promise such as:
  • A reduction in diabetic peripheral neuropathy (nerve-related pain)
  • 15% Increased cardiac output for increased athletic performance
  • Combating muscle cramps and restless leg syndrome (RLS)
Introducing MegaQuinone – The World’s Most Complete Vitamin K2 Supplement

Kiran has been working with raw materials for K2 for 15 years, and has helped several companies develop their own K2 products. After experiencing a lot of frustration product stability, quality control and dosing, Kiran and the Microbiome Labs team decided to product their own K2. MegaQuinone is the result.

Stability - It features a very stable compound which does not degrade and reduce potency. MegaQuinone is the only all-natural pharmaceutical-grade K2 on the market with 100% potency guaranteed.
Optimum Dose – 150 micrograms is generally the highest dose you’ll see on the market, but research points toward a larger optimum dose closer to 320 micrograms/day.
This dose has shown a 97% carboxylation of proteins, a good measure of effectiveness. This dose is designed to increase cardiac output, reduce neuropathy, and influence mitochondrial/energy production. Megaquinone is the only product on the market with an optimal dose of 320 micrograms.
Supportive Ingredients – The three main co-factors for Vitamin K2 efficacy (magnesium, zinc, and boron) are included in this formula, as is vitamin K1. MegaQuinone is the only K2 on the market with these essential co-factors included for maximum effectiveness.

Other ingrediants:

Microcrystalline cellulose, vegetable capsule (hydroxypropyl methycellulose)

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